Merck Millipore Chemicals

Analytical reagents from Merck Millipore are specified according to the American ACS standard as well as according to Reag. Ph Eur. Thus, the correspondingly labeled products meet the requirements for reagents of the American and the European Pharmacopoeia.
The reliability of Merck's analytical reagents offers you several advantages at once:

- Conformity with the ACS standard and Reag. Ph Eur
- Fast adaptation to new specification requirements
- Validated analytical methods
- Comprehensive range of analytical reagents
- Lower costs due to reliable audits
- Reduced validation effort due to internationally consistent product quality

The validation plan for ACS reagents was carried out in accordance with the extremely strict validation instructions for pharmaceutical starting materials (e.g. in accordance with USP and ICH Guideline Q2A "Guidelines for Industry, Text on Validation of Analytical Procedures").

To obtain perfect results in HPLC separation, the use of high-performance solvents is recommended. LiChrosolv® solvents from Merck Millipore are specifically designed for analytical applications using HPLC, fast chromatography and LC-MS and feature high resolution and sensitivity as well as optimized peak baseline separation. They also have a high degree of UV transmittance, low particle counts and low evaporation residue, providing the basis for reliable and reproducible separations. All LiChrosolv® solvents are already microfiltered at 0.2 µm.

For analytical HPLC we offer LiChrosolv® solvents in the purity grades isocratic grade and gradient grade. Solvents in the purity grade gradient grade allow minimization of the flow effect of the respective solvent - for example during an enatiomeric separation on a chiral phase - and are suitable for use in UPLC and UHPLC.
Merck Millipore LiChrosolv® hypergrade solvents are suitable for detection by fast chromatography and LC-MS. LiChrosolv® hypergrade solvents are particularly recommended for LC-MS, as they meet all the requirements of modern LC-MS ionization methods (ESI / APCI - positive and negative mode). Due to their low ionic background and low ion suppression, LiChrosolv® hyper solvents provide high reproducibility of analytical results, as well as high ionization efficiency.

LiChrosolv® hypergrade from Merck Millipore for LC-MS

Due to its very low detection limit, liquid chromatography-mass spectroscopy (LS-MS) is in particular demand in the pharmaceutical and biotech industries. The latest generation LiChrosolv® hypergrade from Merck Millipore meets all requirements of LC-MS ionization methods (ESI/APCI - positive and negative) and delivers best quantitative results in triple quadrupole systems. Due to their low ionic background and low ion suppression, LiChrosolv® hypergrade solvents provide high reproducibility of analytical results, as well as high ionization efficiency. The quality of the solvents is characterized by lowest background noise and thus ensures highest sensitivity of the measuring system. Even the smallest amounts of an analyte can thus still be detected. The packaging material has also been further improved to precisely meet the quality requirements of LC-MS. With the LiChrosolv® product line and its further development, Merck Millipore continues to set new standards to increase the efficiency of HPLC chromatography.

Isocratic and gradient elution

The basic requirements for high-performance solvents are: high UV transmittance, particle-free, low acidity and alkalinity, and low evaporation residue. LiChrosolv® solvents offer all this, ensuring optimal reproducible separations in HPLC. Only carefully selected raw materials are used for their production, which undergo several purification steps before final filling. In analytical HPLC, separations are usually performed with a solvent gradient. For this reason, Merck Millipore offers the corresponding solvents not only with isocratic grades but also with a gradient suitability test ("Gradient Grade"). This allows you to minimize the gradient effect of the solvent involved - for example when separating enantiomers on chiral phases.

Solvents used in preparative chromatography must not only ensure optimal purity and separation speed. They must also minimize wear and tear on your valuable equipment, and they must be able to be used efficiently and safely, even in larger quantities. Merck Millipore's Prepsolv® product line is specifically tailored to the requirements of preparative chromatography.

Merck has tailored its Prepsolv® range of solvents to the requirements of preparative HPLC to facilitate scale-up from analytical to preparative separations. With their high purity, extremely low evaporation residues (< 1 mg/l) and low water content, Prepsolv® solvents for preparative chromatography ensure optimal protection for columns and provide maximum reproducibility of final results.

In systems using large amounts of solvents, optimal separation results depend on a continuous and accurate solvent supply. For Prepsolv®, Merck offers different packaging sizes and delivery concepts for maximum flexibility. Our packaging is definitely inert to the chemical content, ready for repeated transport and optimized for safe and easy handling. Solvents for large-scale applications are supplied in reusable stainless steel drums or containers. Customized quantities and tailor-made concepts are also available. In addition, Merck offers a comprehensive range of withdrawal systems for easy solvent dispensing without risk of contamination.

Highest purity, consistent product quality and proven safety - these are the core features of all EMSURE® solvents. Whether for complex applications or routine analyses, Merck Millipore's premium brand EMSURE® achieves an exceptional level of quality and consistency thanks to its unsurpassed specifications.
EMSURE® products are ideal for demanding analytical procedures with low detection limits and particularly high sensitivity, as well as for method development, due to their outstanding chemical purity and extremely low limits. Thanks to the excellent batch-to-batch consistency, you benefit from reproducible results and thus also from reduced analysis costs, as repetitions of analyses are no longer necessary.

EMSURE® for analysis according to ACS, ISO, Reag. Ph Eur.

The majority of EMSURE® specifications not only meet the requirements of ACS, Reag. Ph. Eur. and ISO guidelines, but even exceeds them. New parameters are added on a regular basis. EMSURE® products can be used worldwide for virtually all applications including pharmacopoeial analysis.
Due to their comprehensive specifications, EMSURE® products are also suitable for the latest technologies, such as trace metal detection using atomic absorption spectroscopy (AAS).

EMPARTA® products are the ideal choice for routine tasks in analytical laboratories. This range offers fewer specified parameters than the EMSURE® range, but meets all important parameters as well as the requirements of the American Chemical Society (ACS). Thus, EMPARTA® products are suitable for quality control according to USP-NF.

EMPARTA® inorganic reagents and solvents offer high analytical purity of 99.0-99.5% and are the cost-effective choice for all standard analytical applications.

For many applications, you don't need solvents of the highest purity, but a cost-effective alternative with solvents that are also available in large containers and whose quality you can rely on. EMPURA® inorganic reagents and solvents are ideal for basic lab work and production applications. These cost-effective products are available in a variety of pack sizes.