The Japanese manufacturer Nacalai Tesque is known for its Cosmosil HPLC columns. At Analytics-Shop you will find a wide range of HPLC columns from Nacalai Tesque in various specifications. Please use our HPLC column configurator to find the right column for you.
More information can be found down below.
The ‘Superb’ packing technique developed by Nacalai Tesque is used to produce the highly efficient HPLC columns. Totally porous silica particles are used, so that COSMOSIL columns have a higher chemical and mechanical stability as well as outstanding surface properties.
COMSOSIL is based on ultra pure porous spherical silica gel (purity: 99.99% or higher). Low-purity silica gel contains metal impurity which may cause interference in the separation, especially for metal coordination compounds.
The silanols (Si-OH groups) on the silica surface provided bonding site for stationary phases. However, part of the silanol groups remain un-capped as residual silanol groups even after the end-capping treatment, they cause peak tailing for basic compounds. COSMOSIL packing materials for reversed phase chromatography are of near-perfectly end-capped residual silanol groups.
Separation Method | Packing Material | Properties |
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Reversed Phase | 3C18-EB | Excellent for standard analyses Packing Material: Silica, 3 µm |
C18-MS-II | Multipurpose-C18 column Monofunctional silylation of high-purity silica gel for almost any separation |
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C18-AR-II | High acid resistance Suitable for acidic samples and peptides |
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C18-PAQ | Compatible with 100 % aqueous mobile phases Suitable for hydrophilic solutions |
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Cholester | Increased separation performance due to rigid cholesteryl structures Comparable applications to C18 |
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πNAP | Stronger π-π interaction than with phenyl columns | |
PYE | Offers the strongest π-π interactions of all columns | |
NPE | Separation through π-π and dipole-dipole interactions | |
PBB-R | Separation through the use of dispersion forces | |
C22-AR-II | HPLC column with alkyl chains | |
C8-MS | HPLC column with alkyl chains | |
C4-MS | HPLC column with alkyl chains | |
TMS-MS | HPLC column with alkyl chains | |
PE-MS | π-π interaction between product and stationary phase | |
CN-MS | High reproducibility using isocratic elutions | |
Normal Phase | SL-II | Suitable for preparative separations |
Hydrophobe Interactions |
HILIC | Retains highly polar components that would be eluted at C18 |
Separation Method | Packing Material | Properties |
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Hydrophobe Interactions |
Sugar-D | Suitable for mono- and disaccharides |
NH2-MS | HPLC column that binds primary amines |
Separation Method | Packing Material | Properties |
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Reversed Phase | Protein-R | High separation performance and separation rate, acid-resistant |
C18-AR-300 | Reversed phase HPLC column with different pore sizes | |
C8-AR-300 | Reversed phase HPLC column with different pore sizes | |
C4-AR-300 | Reversed phase HPLC column with different pore sizes | |
Ph-AR-300 | Reversed phase HPLC column with different pore sizes | |
Gel Permeation | Diol-120-II | Silica-based gel filtration Separation of pore sizes: 5 000 - 100 000 |
Diol-300-II | Silica-based gel filtration Separation of the pore sizes: 10 000 - 700 000 |
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Ion Exchange | Type Q | Anion exchange column for purifications Preferred samples: acidic proteins, DNA |
Type Q-N | Anion exchange column for ultra-fast, precise analyses Preferred samples: acidic proteins, DNA |
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Type S | Cation exchange column for purifications Preferred samples: basic proteins |
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Type SN | Kationenaustausch Säule für ultraschnelle, präzise Analysen Preferred samples: basic proteins |
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Type M | Amphoteric ion exchange column for purifications Preferred samples: any type of protein |
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Type M-N | Amphotere Ionenaustauschsäule für präzise Analysen Preferred samples: any type of protein |
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Hydrophobe Interactions |
HIC | Suitable for the separation of proteins, whereby enzyme activity and quaternary structure are greatly reduced |
Packing Material | Properties |
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Buckyprep | Standard column for the separation of Fullerenes |
Buckyprep-D | Designed for the Separation of Fullerene derivatives |
Buckyprep-M | Designed für die Separation of Metallofullerenes |
PBB | Designed for the separation of C60, C70 |
PYE | Separation of fullerenes and structural isomers |
NPE | Separation of fullerene derivatives |
Separation Method | Packing Material | Properties |
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Gel Permeation | CNT | Suited for the separation of Carbon nanotubes |