RNA based therapeutics represent a powerful new tool for gene therapy. In RNA production, impurities such as nucleotide triphosphates, abortive transcripts, and DNA template can affect down-stream applications by triggering immune responses. Gel-based methods of purification, such as preparative denaturing polyacrylamide gel electrophoresis (PAGE) and agarose gels, are limited by poor resolution of RNA size and potential chemical modifications from reagents such as formaldehyde.
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Additional
Brand
Nacalai Tesque
Column description
Cosmosil
Package specification
SEC
Inner diameter
7.5 mm
mode
Gel-Permeation (GPC/SEC)
Pore size
2000 Å
Length
50 mm
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