Conventionally end-capped C18 columns still have many residual silanol groups on the silica surface of stationary phase that can form ionic bonds with basic compounds. The resulting peak tailing makes accurate quantification of analytes difficult, especially in trace analyses. COSMOSIL 3C18-EB with a better end-capping treatment offers improved peak shape and separation particularly for basic compounds. COSMOSIL 3C18-EB produces sharp peaks using ammonium acetate buffer in LC-MS. 3C18-EB has excellent synthesis reproducibility and column-to-column reproducibility, so it is applicable in routine analysis such as quality control of drugs.
Brand | Nacalai Tesque |
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Carbon load | 15.0% |
Column description | Cosmosil |
Package specification | C18 (RP18, ODS, Octadecyl) |
Endcapping | yes |
Inner diameter | 2 mm |
mode | Reversed Phase (RP) |
Particle Size | 3,0 µm |
Pore size | 120 Å |
USP number | L1 |
Length | 75 mm |