The Aqueous C18 contains a proprietary polar side chain functionally bonded C18 that provides a more well balanced retention profile for both polar and non-polar compounds than a traditional C18. This column can be used with a gradient to retain polar compounds that elute near the void time on a standard C18. The Aqueous C18 provides both high reproducibility and compatibility with a wide variety of mobile phases including 100% aqueous mobile phases. This is an excellent choice for the analysis of a wide variety of compounds by LC/MS screening.